GC–MS analysis, toxicological and oral glucose tolerance assessments of methanolic leaf extract of Eucalyptus globulus

Abstract Background Eucalyptus globulus leaf has shown promising potential in its efficacy to manage some diseases but little is known about safety and use the management of diabetes. This study was designed identify bioactive compounds present extract (EGLEX), assess toxic effects oral glucose tolerance ability. Powdered extracted with methanol using standard extraction procedure. Preliminary phytochemistry, gas chromatography–mass spectrometry (GCMS) analysis extract, acute subacute on (in-vivo) capability were assessed laboratory techniques. Results EGLEX tested positive for presence alkaloids, cardiac glycosides, flavonoids, tannins, phlobatannins terpenoids. Nine identified by GCMS extract. (up 300 mg/kg bwt) showed no toxicity all rats dosed period 14 days. The histomorphological liver kidney tissues harvested from 2000 bwt features histoarchitectural distortions two tissues. (200 further demonstrated effective utilization as insulin metformin. Conclusions results obtained deduced that safe at a lower dose higher bwt, single plant prevented hyperglycemia normal rats.